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Poly(ethylene glycol) methacrylate, average Mn 500

Cat.No ACM25736861-4

Basic Information Description Application Features And Benefits
CAS 25736-86-1
Catalog Number ACM25736861-4
Synonyms Ethoxylated 2-hydroxyethyl methacrylate, Poly(oxy-1,2-ethanediyl), α-(2-methyl-1-oxo-2-propenyl)-ω-hydroxy-, Polyethylene glycol monomethacrylate
Molecular Weight average Mn 500
InChI 1S/C6H10O3/c1-5(2)6(8)9-4-3-7/h7H,1,3-4H2,2H3
InChI Key WOBHKFSMXKNTIM-UHFFFAOYSA-N
Density 1.101 g/mL at 25 °C
Architecture shape: linear
functionality: heterobifunctional
Contains 900 ppm monomethyl ether hydroquinone as inhibitor
MDL Number MFCD00081879
NACRES NA.23
Packaging Packaging
100, 500 mL in glass bottle
Quality Level 100
Refractive Index n20/D 1.467
αEnd methacrylate
ΩEnd hydroxyl
Description Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.
Application Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.
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