Alfa Chemistry has a large selection of basic polymers. Alylamines, ethylenimines, oxazolines, and other polymers with amine groups in their main or side chains are examples of amine-functional polymers.
- Poly(2-oxazoline): Because of its biocompatibility and similar "invisible" qualities, our well-defined poly(2-oxazoline) provides a low-viscosity alternative to PEG for biomedical applications. Poly(2-oxazoline) is made utilizing reactive cationic ring-opening polymerization processes, which results in polymers with highly controlled polymer composition, chain length, structure, and function. To address low water solubility and poor bioavailability of pharmaceuticals, poly(2-oxazoline) has been employed in drug or protein couplings and as polymeric micelles in drug delivery.
Fig 1. Poly(2-oxazoline)-based micro- and nanoparticles.
- Polyethyleneimine: The polycationic nature of polyethyleneimine (PEI) determines the cationic polymer's applicability. All secondary amines are found in linear PEIs, whereas primary, secondary, and tertiary amines are found in branching PEIs. PEI is the most extensively researched synthetic cationic polymer for gene delivery. PEIs attach to DNA/RNA by electrostatic interactions and are then absorbed into cells via endocytosis. PEIs come in a range of sizes and topologies, as well as modified variants for improved biocompatibility.
- Wilson P, et al. (2017). "Poly(2-oxazoline)-Based Micro- and Nanoparticles: A Review." European Polymer Journal. 88: 486-515.