Anti-Platelet Adhesion Surface Technology
INQUIRY
In recent years, significant progress has been made in the field of biomaterials, with the majority of these advancements relating to materials modified for biological uses. The overall properties of biomaterials, such as non-toxicity, corrosion resistance, controlled degradability, elastic modulus, and fatigue strength, have long been considered highly relevant to the selection of suitable biomaterials for specific biomedical applications.
The driving force behind surface modification approaches is that it is often difficult or impossible to obtain the desired overall material properties through engineered polymer synthesis. Alfa Chemistry focuses on research to reduce platelet adhesion on modified substrate surfaces, particularly in the area of biomaterials in contact with blood. Our research and application of chemical surface modification of polymeric biomaterials is extensive and effective and fruitful. If you would like to quickly modify the surface of your product for biomedical applications, please contact us.
Anti-Fouling Surface Technology Platform
When blood comes in contact with biological material, it starts with protein adsorption. Because it binds to platelet GP IIb/IIIa receptors and tends to adsorb to the material's surface, fibrinogen (Fg) is one of the most essential types of absorption proteins that mediate platelet adhesion. To passivate the surface of anti-platelet adhesion materials, Alfa Chemistry often uses chemical modification, such as immobilizing PEG or grafting hydrophilic polymers, amphiphilic polymers, or bioactive compounds.
More information on surface modification techniques can be found in the following.
| Strategies | Grafting | Methods | Results |
|---|
| Immobilize PEG | PEG | Grafting PEG onto submicron textured poly(urethaneurea) biomaterial surfaces | Increased efficiency in reducing platelet adhesion/activation and bacterial adhesion/biofilm formation |
| Protein-reactive PEG | Treat fibrinogen-adsorbed polyurethane with protein-reactive PEG | Reduce platelet adhesion and acute thrombotic deposition |
| Graft bioactive molecules | Heparin | Heparin was immobilized on protonated plasma polymerized allylamine (PPAam) membranes. | Reduces platelet adhesion and activation, improves anticoagulant properties, and exhibits excellent blood compatibility. |
| Arg-Glu-Asp-Val (REDV) peptide | The REDV peptide was immobilized on a random copolymer of carboxymethacrylate (CBMA) and butyl methacrylate (BMA). | Reduces platelet adhesion and activation, exhibits good hemocompatibility, and achieves cell selectivity. |
| Graft zwitterionic polymers | Polybetaine derivatives (polyphosphobetaines and polysulfobetaines) | Transplantation of polybetaine derivatives from cellulose membranes (CM) by SI-ATRP. | Improves resistance to non-specific protein adsorption and has excellent resistance to platelet adhesion. |
| Poly(sulfobetaine methacrylate) (PSBMA) | PSBMAs were prepared on polyethersulfone (PES) membranes. | Exhibit low BSA and BFG adsorption, inhibits platelet adhesion and prolongs clotting time. |
Due of its high mechanical qualities and chemical stability under biological conditions, polytetrafluoroethylene (PTFE) is one of the newest research hotspots. Alfa Chemistry surface functionalizes PTFE substrates using a hybrid technique that includes plasma treatment and chemical reaction. The plasma pretreatment enhances the stability of the polydopamine (PDA) coating, and the chemical reaction grafting MPC onto the PTFE surface. The modified PTFE substrate reduces Fg adsorption significantly, and this hybrid treatment combining plasma and chemical therapy may be able to prevent blood cell responses.
Fig 1. Physical and bioinspired methods were hybridized for functionalization of PTFE surface. Polydopamine layer was stably formed on the surface. Grafting of phospholipid polymers was carried out to reduce protein adsorption. (Cheng B, et al. 2019)
Reference
- Cheng B, et al. (2019). "Surface Functionalization of Polytetrafluoroethylene Substrate with Hybrid Processes Comprising Plasma Treatment and Chemical Reactions." Colloids Surf B Biointerfaces. 173: 77-84.
