With the rapid development of modern medicine, the demand for multifunctional biomedical materials continues to grow. In biomaterials that come into contact with blood, both hemocompatibility and cytocompatibility are crucial, and this is taken into account in many circumstances when developing surface modification procedures. Alfa Chemistry has also made significant progress in the investigation of chemical surface modification strategies for cytocompatible biomaterials in recent years. We improve the biocompatibility of substrates by combining various chemical surface modifications. Our chemical surface modification of materials research and application has proven to be successful and fruitful. Please contact us if you need to fast alter the surface of your product for biomedical applications.
Cytocompatible Surface Surface Strategies
Most of our recent research on changed surface cytocompatibility has been on metallic and inorganic nonmetallic materials such stainless steel, titanium, magnesium alloys, transition metal disulfides, and mesoporous silica. For example, titanium alloys are commonly used due to their good mechanical properties, biocompatibility, and corrosion resistance in simulated body fluids. We changed the surface of titanium alloys to achieve great biocompatibility and cytocompatibility.
We created a novel hybrid oxide-polymer coating by combining the titanium dioxide layer generated by the PEO technique with the biodegradable polymer polyadipic anhydride (PADA). Antibiotic medications can be given directly to the affected spot with regulated release times using biodegradable substrates. The antibacterial and cytocompatible polyadipic anhydride coating is a hybrid layer made up of a titanium porous oxide layer and a PADA layer containing specific medicines. This drug-loaded PADA hybrid layer allows for the creation of biomaterials that are both antibacterial and cytocompatible.
Fig 1. Antimicrobial and cytocompatible coatings based on polyadipic anhydride for titanium alloy surfaces. (Leśniak-Ziółkowska K, et al. 2020)
The research of cytocompatibility is also crucial for polymeric biomaterials' biological uses. Alfa Chemistry has devised a number of ways for imparting hydrophilic and biomolecular rejection features to PDMS surfaces of microfluidic polymeric biomaterials in order to improve antifouling properties and broaden the uses of PDMS-based microfluidic systems. For PDMS surface modification, we applied improved photocatalytic methods involving polysaccharides such as CMC, CMD, and alginate. The polysaccharide modification dramatically improved the cytocompatibility and vitality of cells cultivated on the modified substrate.
In the case of medical implants, we want to modify the surface properties without affecting the propriety properties to achieve anti-fouling, hemocompatibility and tissue growth promoting properties. By generating reactive oxygen species (ROS) under UV irradiation, we have developed multilayer films with multiple functions that promote cell adhesion and tissue regeneration.
Fig 2. Schematic illustration of the preparation of P(PA-co-AA) assembled with chitosan to form multilayers on the substrate surface. P(PA-co-AA) generates ROS in multilayers after decomposition under UV irradiation, thereby disrupting bacterial biofilms and then allowing cells to adhere and proliferate. (Zhang H, et al. 2019)
To generate a multilayer coating on the substrate's surface, poly(pyrene methacrylate-co-acrylic acid) (P(PA-co-AA) is blended with chitosan. Multilayer UV groups can increase cell adhesion and proliferation, particularly after biofilm removal, implying that multilayer films are cytocompatible and can promote tissue growth and implant integration.
Please contact us for more technical information on enhancing surface cytocompatibility.
References
- Leśniak-Ziółkowska K, et al. (2020). "Antibacterial and Cytocompatible Coatings Based on Poly(Adipic Anhydride) for A Ti Alloy Surface." Bioactive Materials. 5(3): 709-720.
- Liu X, et al. (2019). "UV-Responsive Multilayers with Multiple Functions for Biofilm Destruction and Tissue Regeneration." ACS Appl. Mater. Interfaces. 11: 17283-17293.
