Surface Coating / Alfa Chemistry

Drug Coatings


A drug-device combination product (DDCP) is a healthcare item that combines one or more pharmaceutical ingredients with one or more medical device ingredients into a single integrated item. In DDCP, drug coatings are critical to the clinical efficacy and safety of the product. The idea and optimization of the coating design demands significant attention due to the intricacy of DDCP development.

Alfa Chemistry is a drug coatings pioneer. Almost every unique DDCP design can benefit from our coating technology and process understanding. To ensure maximum clinical performance, these coatings consistently supply a wide range of active medicinal ingredients.

Our drug coatings have been shown to increase the clinical safety and efficacy of device medication combination solutions in both research and practice. We have extensive experience in customizing drug coatings for the following applications:

Coatings with Controlled Drug Delivery

Alfa Chemistry creates drug delivery coatings with customized release profiles to ensure that active pharmaceutical components are delivered accurately and that clinical efficacy is optimized.

Drug delivery coating systems for local and long-term drug release have gotten a lot of interest lately, especially when it comes to functionalizing bio-inert implants with osseointegration and antibacterial qualities. Alfa Chemistry used a one-step electrophoretic deposition approach to create a biodegradable drug delivery coating platform made up of drug-loaded PHBV microspheres embedded in an alginate-PVA matrix. Layer-by-layer deposition of chitosan-alginate multilayers on EPD-produced coatings was used to extend the diffusion barrier surrounding the microspheres for controlled medication release.

Drug CoatingsFig 1.Multilayer drug delivery coating composed of daidzein-loaded PHBV microspheres. (Chen Q, et al. 2016)

In sustained-release drug delivery systems, drug particles with nanoscale biodegradable polymer coatings have a wider range of applications. Alfa Chemistry can make nano-scale polylactic acid biodegradable coverings for anti-asthma medicines and insulin delivery. A thin film of polymer produced on 1-5 micron drug particles fluidized in an air chamber is ablated by a pulsed excimer laser. This technique will be examined in relation to anti-asthma medications and insulin delivery. Films produced by pulsed electron beam deposition have better RMS roughness and other morphological features than films deposited by conventional laser ablation.

Drug-Eluting Stent Coatings

Drug-eluting stents (DES) are metal stents with polymers coated on the surface that carry medications. Drugs are released from the polymer covering to the cardiovascular wall tissue in a regulated manner when stents are inserted in intravascular lesions. have biological consequences DES has transformed the treatment of diseases including interventional cardiology and coronary artery disease as medical technology has advanced.

Alfa Chemistry is dedicated to delivering DES coating expertise to your varied revolutionary DES products, making it the right platform for advanced DES coating solution needs. Experienced Alfa Chemistry provides unmatched DES coatings, whether polymer-based, polymer-free or excipient-based. For example, we used a biocompatible poly(styrene-b-isobutylene-b-styrene) block copolymer (SIBS) as a drug-eluting polymer coating on yew coronary stents.

Drug CoatingsFig 2. Polyethylene carbonate-based drug-eluting stents. (Bege N, et al. 2012)


  • Chen Q, et al. (2016). "Multilayered Drug Delivery Coatings Composed of Daidzein-loaded PHBV Microspheres Embedded in a Biodegradable Polymer Matrix by Electrophoretic Deposition." J. Mater. Chem. B. 4: 5035-5045.
  • Bege N, et al. (2012). "Drug Eluting Stents Based on Poly(Ethylene Carbonate): Optimization of the Stent Coating Process." European Journal of Pharmaceutics and Biopharmaceutics. 80(3): 562-570.

Our products and services are for research use only and cannot be used for any clinical purpose.

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