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Triethylene glycol monomethyl ether

Cat.No ACM112356-3

Basic Information Description Application Features And Benefits
CAS 112-35-6
Catalog Number ACM112356-3
Synonyms Methyltriglycol
IUPAC Name 2-[2-(2-methoxyethoxy)ethoxy]ethanol
Molecular Weight 164.20
Molecular Formula C7H16O4
Canonical SMILES COCCOCCOCCO
InChI InChI=1S/C7H16O4/c1-9-4-5-11-7-6-10-3-2-8/h8H,2-7H2,1H3
InChI Key JLGLQAWTXXGVEM-UHFFFAOYSA-N
Boiling Point 122 °C at 10 mmHg (lit.)
Melting Point -45°C (lit.)
Flash Point 118ºC
Purity purum, ≥97.0% (GC)
Density 1.026 g/mL at 25 °C (lit.)
Solubility 6.09 M;In water, miscible;Soluble in water;Solubility in heptane = 1.5 wt%, completely soluble in acetone, benzene, ethyl ether, methanol, and carbon tetrachloride at 25 °C.;Solubility in water: miscible
Appearance Liquid
Assay 95%
Autoignition Temperature 210 °C
Beilstein REAXYS Number 1700198
EC Number 203-962-1
MDL Number MFCD00002875
NACRES NA.23
Packaging Packaging
2 L in poly bottle
25, 500 mL in poly bottle
PubChem ID 24859069
Quality Level 200
Refractive Index 1.439
Vapor Density 5.66
Vapor Pressure <0.01 mm Hg ( 20 °C)
Viscosity 7 centistokes at 25 °C
Description Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.
Application Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.
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