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Tri(ethylene glycol) bis(chloroformate)

Cat.No ACM17134177-1

Basic Information Description Application Features And Benefits
CAS 17134-17-7
Catalog Number ACM17134177-1
IUPAC Name 2-[2-(2-carbonochloridoyloxyethoxy)ethoxy]ethyl carbonochloridate
Molecular Weight 275.08
Molecular Formula C8H12Cl2O6
Canonical SMILES ClC(=O)OCCOCCOCCOC(Cl)=O
InChI 1S/C8H12Cl2O6/c9-7(11)15-5-3-13-1-2-14-4-6-16-8(10)12/h1-6H2
InChI Key IFOIGJKHVZBFPR-UHFFFAOYSA-N
Density 1.34 g/mL at 25 °C (lit.)
Assay 96%
MDL Number MFCD00011536
NACRES NA.23
PubChem ID 24858190
Quality Level 100
Refractive Index n20/D 1.457 (lit.)
Storage Temperature 2-8°C
Vapor Pressure 0.09 psi ( 20 °C)
Description Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.
Application Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.
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