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Tetraethyleneglycol monomethyl ether

Cat.No ACM23783428-2

Basic Information Description Application Features And Benefits
CAS 23783-42-8
Catalog Number ACM23783428-2
IUPAC Name 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol
Molecular Weight 208.25, average Mn 200
Molecular Formula C9H20O5;HO(CH2CH₂O)4CH3;C9H20O5
Canonical SMILES COCCOCCOCCOCCO
InChI 1S/C9H20O5/c1-11-4-5-13-8-9-14-7-6-12-3-2-10/h10H,2-9H2,1H3
InChI Key ZNYRFEPBTVGZDN-UHFFFAOYSA-N
Boiling Point 280-350 °C
Melting Point -39 °C
Flash Point 161 °C c.c.
Density 1.045 g/mL at 25 °C
Solubility Solubility in water: miscible
Autoignition Temperature 325 °C
EC Number 245-883-5
Grade technical grade
MDL Number MFCD00041756
NACRES NA.23
PubChem ID 329762545
Quality Level 100
Refractive Index n20/D 1.444
Vapor Density Relative vapor density (air = 1): 7.2 (calculated)
Vapor Pressure Vapor pressure, Pa at 20 °C:
Viscosity 11.5-12.5 mm2/s at 20 °C
αEnd methoxy
ΩEnd hydroxyl
Description Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.
Application Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.
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