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Tetraethylene glycol dimethyl ether

Cat.No ACM143248-2

Basic Information Description Application Features And Benefits
CAS 143-24-8
Catalog Number ACM143248-2
Synonyms Dimethoxytetraethylene glycol, 2,5,8,11,14-Pentaoxapentadecane, Bis[2-(2-methoxyethoxy)ethyl] ether, Dimethyltetraglycol, Tetraglyme
IUPAC Name 1-methoxy-2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethane
Molecular Weight 222.28
Molecular Formula C10H22O5
Canonical SMILES COCCOCCOCCOCCOC
InChI 1S/C10H22O5/c1-11-3-5-13-7-9-15-10-8-14-6-4-12-2/h3-10H2,1-2H3
InChI Key ZUHZGEOKBKGPSW-UHFFFAOYSA-N
Boiling Point 275-276 °C (lit.)
Melting Point −30 °C (lit.)
Density 1.009 g/mL at 25 °C (lit.)
Architecture shape: linear
functionality: homobifunctional
Assay ≥99%
≥99.0% (GC)
Autoignition Temperature 510 °F
Beilstein REAXYS Number 1760005
EC Number 205-594-7
MDL Number MFCD00008505
NACRES NA.23
Packaging Packaging
250 g in glass bottle
1 kg in glass bottle
PubChem ID 24850399
Quality Level 200
Refractive Index n20/D 1.432 (lit.)
Vapor Density 7.7 (vs air)
Vapor Pressure <0.01 mmHg ( 20 °C)
Description Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.
Application Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.
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