| Description |
Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. |
| Application |
Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research s. These materials have been used in many s such as signal amplification in bioassays and in drug delivery s. Both the carboxylic acid-functionalized dendrimers and amine-functionalized (after Boc deprotection) core can be readily used in EDC or DCC coupling reactions with amine or carbonyl-containing compounds, respectively, to yield highly functionalized materials for a variety of biomedical s. |
| Features And Benefits |
Polymer architecture: Dendron
Generation: 2
Core functional group: Boc-protected amine
End group functionality: Carboxylic acid
No. surface groups: 4
Calculated mol. wt.: 1114.06 g/mol
Boc: tert-Butyloxycarbonyl
bis-MPA: 2,2-Bis(hydroxymethyl)propionic acid
Polyester bis-MPA dendron (4 carboxyl, 1 NHBoc (core), generation 2), a high generation dendron, is synthesized by using anhydride activated bis-MPA monomers via divergent growth. It has a large and exact number of reactive groups and has dual functionalization capacity that makes it useful as a high-value scaffold. |
