Surface Coating / Alfa Chemistry

Poly(ethylene glycol) tetrahydrofurfuryl ether

Cat.No ACM31692850-2

Basic Information Description Application Features And Benefits
CAS 31692-85-0
Catalog Number ACM31692850-2
Synonyms Mixture of diethylene and triethylene glycol mono-tetrahydrofurfuryl ether, Tetrahydrofurfuryl polyethylene glycol 200
IUPAC Name 2-(oxolan-2-ylmethoxy)ethanol
Molecular Weight average Mn 200
Molecular Formula C7H14O3
InChI 1S/C7H14O3/c8-3-5-9-6-7-2-1-4-10-7/h7-8H,1-6H2
Density 1.069 g/mL at 25 °C (lit.)
EC Number 227-407-8
MDL Number MFCD00801146
Quality Level 100
Refractive Index n20/D 1.462 (lit.)
αEnd tetrahydrofurfuryl ether
ΩEnd hydroxyl
Description Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.
Application Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.
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