Surface Coating / Alfa Chemistry

Poly(ethylene glycol) [N-(2-maleimidoethyl)carbamoyl]methyl ether 2-(biotinylamino)ethane

Basic Information Description Application Features And Benefits
Catalog Number ACMA00013953
Synonyms Biotin-PEG, Biotin polyoxyethylene maleimide, Biotin-PEG-maleimide, Biotinylated PEG
Molecular Weight PEG average Mn 5000 (n~110)
average Mn 5,400
Melting Point 47-52 °C
Architecture shape: linear
functionality: heterobifunctional
Packaging Packaging
100 mg in glass insert
Quality Level 100
Storage Temperature −20°C
αEnd biotin
ΩEnd maleimide
Description Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.
Application Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.
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