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Poly(ethylene glycol) diamine, average Mn 10000

Cat.No ACM24991535-9

Basic Information Description Application Features And Benefits
CAS 24991-53-5
Catalog Number ACM24991535-9
Synonyms Poly(ethylene glycol) bis(amine), O,O'-Bis(2-aminoethyl)polyethylene glycol, Polyoxyethylene bis(amine), Diaminopolyethylene glycol, PEG-diamine
Molecular Weight average Mn 10000
InChI 1S/C6H16N2O2/c7-1-3-9-5-6-10-4-2-8/h1-8H2
InChI Key IWBOPFCKHIJFMS-UHFFFAOYSA-N
Melting Point 56-60 °C
Architecture shape: linear
functionality: homobifunctional
MDL Number MFCD00132004
NACRES NA.23
Packaging Packaging
1, 5 g in glass bottle
Quality Level 100
αEnd amine
ΩEnd amine
Description Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.
Application Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.
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