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Poly(ethylene glycol), average Mn 4000

Cat.No ACM25322683-21

Basic Information Description Application Features And Benefits
CAS 25322-68-3
Catalog Number ACM25322683-21
Synonyms PEG
Molecular Weight Mn 3,500-4,500
average Mn 4000
Canonical SMILES C(CO)O
InChI 1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
InChI Key LYCAIKOWRPUZTN-UHFFFAOYSA-N
Melting Point 58-61 °C
Form powder
MDL Number MFCD00081839
NACRES NA.23
Packaging Packaging
5 kg in glass bottle
1 kg in poly bottle
PubChem ID 24887706
Quality Level 200
Storage Temperature 2-8°C
αEnd hydroxyl
ΩEnd hydroxyl
Description Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.
Application Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.
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