Surface Coating / Alfa Chemistry

Poly(ethylene glycol), average Mn 400

Cat.No ACM25322683-40

Basic Information Description Application Features And Benefits
CAS 25322-68-3
Catalog Number ACM25322683-40
Synonyms PEG
Molecular Weight Mn 380-420
average Mn 400
Canonical SMILES C(CO)O
InChI 1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
Melting Point 4-8 °C (lit.)
Density 1.128 g/mL
Form viscous liquid
MDL Number MFCD00081839
Packaging Packaging
250, 500 g in poly bottle
20 kg in poly drum
5 g in glass bottle
PubChem ID 24852060
Quality Level 200
Refractive Index n20/D 1.466
αEnd hydroxyl
ΩEnd hydroxyl
Description Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.
Application Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.
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