Surface Coating / Alfa Chemistry

Poly(ethylene glycol) 2-aminoethyl ether acetic acid, average Mn 2100

Basic Information Description Application Features And Benefits
CAS 139729-28-5
Catalog Number ACM139729285-3
Synonyms Aminopolyoxyethylene acetic acid, AminoPEG carboxylic acid, Amine-PEG-carboxylic acid, Amino-PEG acetic acid
Molecular Weight PEG average Mn 2000 (n~45)
average Mn 2,100
Melting Point 55-61 °C
Architecture shape: linear
functionality: heterobifunctional
Form solid
Quality Level 100
Storage Temperature −20°C
αEnd carboxylic acid
ΩEnd amine
Description Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.
Application Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.
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