Surface Coating / Alfa Chemistry

Poly(D,L-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(D,L-lactide-co-glycolide) based poly(ether ester urethane)

Cat.No ACMA00003231

Basic Information Description Application Features And Benefits
Catalog Number ACMA00003231
Synonyms poly(ester ether urethane), PLGA-PEG-PLGA urethane, PEEU
Molecular Weight PEG average Mn 400
average Mn (6,000-15,000)
Molecular Formula [C2H2N2O2R[(C3H4O2)x(C2H2O2)y]m[C2H4O]lO[(C3H4O2)x(C2H2O2)y]m]n
Form amorphous solid
Packaging 1, 5 g in glass bottle
PubChem ID 329768204
Quality Level 100
Storage Temperature 2-8°C
Description The polymers are bioresorbable aliphatic polyesters comprised of a range of different ratios of lactide and glycolide monomers, PLA stereochemistries, and end-group functionalization. These biodegradeable homopolymers and copolymers of lactide and glycolide afford a variety of properties that range from very stiff, hard semi-crystalline materials with long degradation times, to softer, amorphous materials with faster degradation rates.
Application This poly(ether ester urethane) based on PLGA-PEG-PLGA triblock copolymers linked with a diisocyanate is a biodegradable, resorbable gel former for use in drug delivery systems.
Features And Benefits This polymer doesn't rely on temperature or pH to induce gelation, and therefore forms more consistent and faster-setting drug delivery depots. Through combination of various gel formers and/or diluents, drug release profiles may be modulated to exhibit fast burst release through extended (up to 1 month) zero-order release profile. Mass loss of the resultant drug delivery depots is complete within 4 months.

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