Poly(D,L-lactide-co-glycolide)(85/15)-b-poly(ethylene glycol)-carboxylic acid, 5k-13k

Basic Information Description Application Features And Benefits

Catalog Number	ACMA00040490
Synonyms	PLGA-PEG-COOH, PLGA-PEG, PLGA-b-PEG, PLGA-PEG Carboxylic acid diblock copolymer
Molecular Formula	HO(CH(CH3)COO)x(CH2COO)y(CH2CH2O)nH
NACRES	NA.23
Quality Level	100
Storage Temperature	2-8°C

Description The polymers are bioresorbable aliphatic polyesters comprised of a range of different ratios of lactide and glycolide monomers, PLA stereochemistries, and end-group functionalization. These biodegradeable homopolymers and copolymers of lactide and glycolide afford a variety of properties that range from very stiff, hard semi-crystalline materials with long degradation times, to softer, amorphous materials with faster degradation rates.

Application Biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic Poly(lactide-co-glycolide) (PLGA) block, functionalized with a terminal carboxylic acid. These materials have been used in control release and nanoparticle formulation for drug delivery applications. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymer block. Additionally, the ratio of lactide to glycolide can be tuned to control rate of degradation. Carboxylic acid termination allows for facile further chemical modification of these materials.

Features And Benefits Good biocompatibility;
Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.

Our products and services are for research use only and cannot be used for any clinical purpose.

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