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O-[2-(3-Mercaptopropionylamino)ethyl]-O'-methylpolyethylene glycol

Cat.No ACM401916618-3

Basic Information Description Application Features And Benefits
CAS 401916-61-8
Catalog Number ACM401916618-3
Synonyms PEG-thiol, 'Mercaptopolyethylene glycol monomethyl ether'
IUPAC Name 2-methoxyethanol;2-(2-sulfanylethoxy)ethanol
Molecular Weight 198.28g/mol
Molecular Formula C7H18O4S
Canonical SMILES COCCO.C(COCCS)O
InChI InChI=1S/C4H10O2S.C3H8O2/c5-1-2-6-3-4-7;1-5-3-2-4/h5,7H,1-4H2;4H,2-3H2,1H3
InChI Key PVYJAAVBEMPGMU-UHFFFAOYSA-N
Architecture shape: linear
functionality: monofunctional
MDL Number MFCD00803682
NACRES NA.23
PubChem ID 329749312
Quality Level 100
Storage Temperature −20°C
αEnd methoxy
ΩEnd thiol
Description Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.
Application Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.
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