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N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(ε-caprolactone)

N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(ε-caprolactone)

Cat.No ACMA00040455

Basic Information Description Application Features And Benefits

Catalog Number	ACMA00040455
Synonyms	PEG-PCL, NHS ester-PEG-PCL, PEG-b-PCL, NHS ester PEG-PCL diblock copolymer
Molecular Weight	PCL average Mn 5,000 PEG average Mn 5,000
Molecular Formula	C10H14NO5S[C2H4O]n[C6H10O2]mH
Form	powder or solid
Quality Level	100
Storage Temperature	−20°C

Description N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(ε-caprolactone) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block.

Application These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters. The NHS ester functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Features And Benefits Good biocompatibility;
Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.