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Carboxylic acid-poly(ethylene glycol)-b-poly(lactide-co-glycolide)

Carboxylic acid-poly(ethylene glycol)-b-poly(lactide-co-glycolide)

Basic Information Description Application Features And Benefits

Catalog Number	ACMA00040487
Synonyms	COOH-PEG-PLGA, Carboxylic acid PEG-PLGA
Molecular Weight	PEG average Mn 5,000 (by NMR) PLGA average Mn 20,000 (by NMR)
Molecular Formula	H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nC2H3O2
Form	powder or chunks
Quality Level	100
Storage Temperature	−20°C

Description Carboxylic acid-poly(ethylene glycol)-b-poly(lactide-co-glycolide) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLGA block.

Application These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). The carboxylic acid functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Features And Benefits Good biocompatibility;
Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.