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Carboxylic acid-poly(ethylene glycol)-b-poly(ε-caprolactone), PEG Mn 2000, PCL Mn 5000

Carboxylic acid-poly(ethylene glycol)-b-poly(ε-caprolactone), PEG Mn 2000, PCL Mn 5000

Cat.No ACMA00040444

Basic Information Description Application Features And Benefits

Catalog Number	ACMA00040444
Synonyms	Carboxylic acid-PEG-PCL, PEG-PCL, PEG-b-PCL, Carboxylic acid PEG-PCL diblock copolymer
Molecular Weight	PCL average Mn 5,000 (by NMR) PCL average Mn 5,000 PEG average Mn 2,000 (by NMR) PEG average Mn 2,000
Molecular Formula	C3H5O3[C2H4O]n[C6H10O2]mH
Canonical SMILES	[H]OCCCCCC(OCCOCCC(O)=O)=O
Form	powder or chunks
Quality Level	100
Storage Temperature	−20°C

Description Carboxylic acid-poly(ethylene glycol)-b-poly(ε-caprolactone) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block.

Application These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters. The carboxylic acid functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Features And Benefits Good biocompatibility;
Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.